Laboratory of Cell and Membrane Biology
Our research interests
- Anthrax Toxin: Determine the molecular mechanisms by which Anthrax toxin hijacks cellular mechanisms to achieve the most efficient intoxication.
- TEM8 and CMG2: Understand the physiological and pathological roles of these anthrax toxin receptors.
- Hyaline Fibromatosis Syndrome, a rare genetic disease due to mutations in CMG2: what are the mechanisms responsible for the symptoms, what are the molecular consequences of the patient mutations
- Compartmentalization of mammalian cells and cell membranes: what are the molecules and mechanisms involved, with a special focus on the endoplasmic reticulum and the plasma membrane.
- Palmitoylation, the only reversible lipid post-translational modification of proteins: how does this modification control protein networks by affecting their function and localization.
- Bacterial Pore-Forming toxins, with a special focus on aerolysin: what is their structure at different stages of their mode of action? How do cells respond to damage inflicted by this class of toxins?
Short Biography of Professor F. Gisou van der Goot, Head of Laboratory
Gisou van der Goot studied engineering at the Ecole Centrale de Paris, then did a PhD in Molecular Biophysics at the Nuclear Energy Research Center, Saclay, France, followed by a postdoc at the European Molecular Biology Laboratory (EMBL) in Heidelberg. She started her own group in 1994 in the department of Biochemistry, University of Geneva, became Associate professor at the Faculty of Medicine (Univ. Geneva) in 2001 and finally Full Professor at the EPFL in 2006, where she co-founded the Institute of Global Health. In 2014, she was appointed Dean of EPFL’s School of Life Sciences.