Oksana Sergeeva

Determine the molecular mechanisms by which Anthrax toxin hijacks cellular mechanisms to achieve the most efficient intoxication.  

Anthrax toxin

Jérome Bürgi, Sarah Friebe, Béatrice Kunz, Olha Novokhatska

Unravel the physiological and pathological roles of Anthrax toxin receptors.

TEM8 and CMG2

Jérome Bürgi, Béatrice Kunz, Olha Novokhatska

A rare genetic disease due to mutations in CMG2: understand the mechanisms responsible for the symptoms and the molecular consequences.

Hyaline Fibromatosis Syndrome

Laurence Abrami, Mathieu Blanc, Mustafa Demir, Sylvia Ho, Elsa Perrody, Patrick Sandoz

What are the molecules and mechanisms involved, with a special focus on the endoplasmic reticulum and the plasma membrane.

Compartmentalization of mammalian cells and cell membranes

Laurence Abrami, Mustafa Demir, Tiziano Dallavilla, Mathieu Blanc, Elsa Perrody, Patrick Sandoz

The only reversible post-translational modification of proteins: how does this modification control protein networks by affecting their function and localization.

Palmitoylation and ER function

Laurence Abrami, Sylvia Ho, Oksana Sergeeva

With a special focus on aerolysin: what is their structure at different stages of their mode of action? How do cells respond to damage inflicted by this class of toxins?

Bacterial Pore-Forming toxins